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Multiple Sclerosis

New England Journal of Medicine
NEJM ? Collection Updates for Multiple Sclerosis
The New England Journal of Medicine (NEJM) RSS feed ? collection updates for Multiple Sclerosis. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

ORIGINAL ARTICLE: B-Cell Depletion with Rituximab in Relapsing?Remitting Mult...
by Stephen L. Hauser, M.D., Emmanuelle Waubant, M.D., Ph.D., Douglas L. Arnold, M.D., Timothy Vollmer, M.D., Jack Antel, M.D., Robert J. Fox, M.D., Amit Bar-Or, M.D., Michael Panzara, M.D., Neena Sarkar, Ph.D., Sunil Agarwal, M.D., Annette Langer-Gould, M.D., Ph.D., and Craig H. Smith, M.D., for the HERMES Trial Group
21 Aug 2008 at 2:00pm
Background: There is increasing evidence that B lymphocytes are involved in the pathogenesis of multiple sclerosis, and they may be a therapeutic target. Rituximab, a monoclonal antibody, selectively targets and...
PERSPECTIVE: The B Cell ? Old Player, New Position on the Team
21 Aug 2008 at 2:00pm
A phase 2 clinical trial of rituximab in the treatment of multiple sclerosis reported by Hauser et al. in this issue of the Journal (pages 676?688) provides important insights into...
EDITORIAL: Old Suspects Found Guilty ? The First Genome Profile of Multiple S...
by Leena Peltonen, M.D., Ph.D.
High-resolution genomewide association studies using panels of 300,000 to 1 million single-nucleotide polymorphisms (SNPs) aim to define genetic risk profiles of common diseases. These studies herald a fundamentally new opportunity...
CLINICAL THERAPEUTICS: Natalizumab for Multiple Sclerosis
by Richard M. Ransohoff, M.D.
21 Aug 2008 at 9:00pm
A 30-year-old woman was evaluated for consideration of treatment options for multiple sclerosis. Two years earlier she had reported having vertigo. The diagnosis of multiple sclerosis was confirmed by clinical...
ORIGINAL ARTICLE: Natural History of Multiple Sclerosis with Childhood Onset
by Christel Renoux, M.D., Sandra Vukusic, M.D., Yann Mikaeloff, M.D., Gilles Edan, M.D., Michel Clanet, M.D., Bénédicte Dubois, M.D., Marc Debouverie, M.D., Bruno Brochet, M.D., Christine Lebrun-Frenay, M.D., Jean Pelletier, M.D., Thibault Moreau, M.D., Catherine Lubetzki, M.D., Patrick Vermersch, M.D., Etienne Roullet, M.D., Laurent Magy, M.D., Marc Tardieu, M.D., Samy Suissa, Ph.D., and Christian Confavreux, M.D., for the Adult Neurology Departments KIDMUS Study Group
21 Aug 2008 at 9:00pm
Background: The course and prognosis of childhood-onset multiple sclerosis have not been well described.

Methods: We used data from 13 adult neurology departments affiliated with the European Database for Multiple Sclerosis...
ORIGINAL ARTICLE: Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis
by Ludwig Kappos, M.D., Jack Antel, M.D., Giancarlo Comi, M.D., Xavier Montalban, M.D., Paul O'Connor, M.D., Chris H. Polman, M.D., Tomas Haas, Ph.D., Alexander A. Korn, Ph.D., Goeril Karlsson, Ph.D., and Ernst W. Radue, M.D., for the FTY720 D2201 Study Group
21 Aug 2008 at 2:00pm
Background: Fingolimod (FTY720) is a new oral immunomodulating agent under evaluation for the treatment of relapsing multiple sclerosis.

Methods: We randomly assigned 281 patients to receive oral fingolimod, at a dose...
ORIGINAL ARTICLE: Natalizumab plus Interferon Beta-1a for Relapsing Multiple ...
by Richard A. Rudick, M.D., William H. Stuart, M.D., Peter A. Calabresi, M.D., Christian Confavreux, M.D., Steven L. Galetta, M.D., Ernst-Wilhelm Radue, M.D., Fred D. Lublin, M.D., Bianca Weinstock-Guttman, M.D., Daniel R. Wynn, M.D., Frances Lynn, M.Sc., Michael A. Panzara, M.D., M.P.H., and Alfred W. Sandrock, M.D., Ph.D., for the SENTINEL Investigators
21 Aug 2008 at 2:00am
Background: Interferon beta is used to modify the course of relapsing multiple sclerosis. Despite interferon beta therapy, many patients have relapses. Natalizumab, an ?4 integrin antagonist, appeared to be safe...
EDITORIAL: Patients at Risk
by Jeffrey M. Drazen, M.D.
In clinical trials, the term ?patients at risk? refers to the altruistic people who volunteer to participate in studies of novel treatments. In this issue of the Journal, three reports123...

Multiple Sclerosis News From Medical News Today
Latest Multiple Sclerosis News From Medical News Today.

World-Class MS Information At The Touch Of A Button
21 Aug 2008 at 12:00pm
People affected by the debilitating neurological condition multiple sclerosis (MS) now have world-class information at their fingertips thanks to a UK first by the MS Society. The charity, which is the largest of its kind supporting people affected by MS, has this week...
Nutra Pharma Announces Initial Positive Safety Data From Clinical Study In Ad...
15 Aug 2008 at 11:00am
Nutra Pharma Corp. (OTCBB: NPHC), a biotechnology company that is developing drugs for HIV and Multiple Sclerosis, has announced that its wholly-owned drug discovery subsidiary, ReceptoPharm, has reported initial positive safety data from its Phase IIb/IIIa clinical study of RPI-7...
European Medicines Agency Update On Progressive Multifocalleukoencephalopathy...
14 Aug 2008 at 11:00am
At the end of July 2008, the European Medicines Agency (EMEA) received two reports of progressive multifocal leukoencephalopathy (PML) in patients with relapsing-remitting multiple sclerosis (MS) who have been treated with Tysabri. PML is a rare brain infection with symptoms that are simila...
BioMS Medical Announces Positive Interim Analysis On Phase III Trial Of Diruc...
14 Aug 2008 at 11:00am
BioMS Medical Corp. (TSX: MS), a leading developer in the treatment of multiple sclerosis (MS), announced that the independent Drug Safety Monitoring Board (DSMB) for the MAESTRO-01 trial has conducted the scheduled interim analysis of efficacy and safety and has recommended that the tria...
Pluristem's PLX-MS Shows Potential Benefit In The Prevention Of Multiple Scle...
13 Aug 2008 at 1:00pm
Pluristem Therapeutics Inc. (NasdaqCM:PSTI) (DAX:PJT) a bio-therapeutics company dedicated to the commercialization of non-personalized (allogeneic) cell therapy products for a variety of degenerative, ischemic and autoimmune indications, today announced that the Company's PLacental eXpanded (PLX...
Pharmaceutical Company Confirms Two Cases Of PML In People With MS Taking Tys...
4 Aug 2008 at 2:00pm
A report from Biogen Idec has confirmed two further cases of progressive multifocal leukoencephalopathy (PML) in people with multiple sclerosis (MS) in the EU. The first person had an aggressive form of MS and had been taking Tysabri for approximately 17 months. They are now in a stable condi...
Multiple Sclerosis: new MRI contrast medium enables early diagnosis in animal...
4 Aug 2008 at 11:00am
In an animal model of multiple sclerosis (MS), neuroradiologists and neurologists of the University hospitals of Heidelberg and Würzburg have been able to visualize inflammatory tissue damage, most of which had remained unrecognized up to now, with the aid of a new contrast medium, Gadofluorine ...
NY Stem Cell Foundation Plays Critical Funding Role In Major New ALS Research
3 Aug 2008 at 10:00am
In a breakthrough discovery, Dr. Kevin Eggan, Chief Scientific Officer of The New York Stem Cell Foundation and Principal Faculty Member of the Harvard Stem Cell Institute, has produced human stem cell lines from the cells of patients afflicted with a version of amyotrophic lateral sclerosis (ALS...

MedWorm: Multiple Sclerosis
MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest headlines from journals and sites in the Multiple Sclerosis category.

The treatment of multiple sclerosis with beta-interferon
by Neuroepidemiology
21 Aug 2008 at 11:05am
Neuroepidemiology 2008;31:157-158 (DOI:10.1159/000151525) (Source: Neuroepidemiology)

 

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Clinical parameters to predict response to interferon in relapsing multiple s...
by Neuroepidemiology
21 Aug 2008 at 11:05am
Neuroepidemiology 2008;31:150-156 (DOI:10.1159/000151524) (Source: Neuroepidemiology)
The prevalence of multiple sclerosis in the middle east
by Neuroepidemiology
21 Aug 2008 at 11:05am
Neuroepidemiology 2008;31:129-137 (DOI:10.1159/000151514) (Source: Neuroepidemiology)
Biopsychosocial correlates of adjustment to pain among people with multiple s...
by The Clinical Journal of Pain
21 Aug 2008 at 1:42am
Page: 559DOI: 10.1097/AJP.0b013e318171cdf1Authors: Douglas, Clint RN, PhD *; Wollin, Judy A. RN, PhD +; Windsor, Carol RN, BA(Hon) * (Source: The Clinical Journal of Pain)
[cochrane corner] multidisciplinary rehabilitation for adults with multiple s...
by Postgraduate Medical Journal
20 Aug 2008 at 6:00am
(Source: Postgraduate Medical Journal)
Designed glycopeptides with different ?-turn types as synthetic probes for th...
by Journal of Medicinal Chemistry
20 Aug 2008 at 6:00am
Alfonso Carotenuto, Maria Claudia Alcaro, Maria Rosaria Saviello, Elisa Peroni, Francesca Nuti, Anna Maria Papini, Ettore Novellino, and Paolo RoveroWeb Release Date: Wed, 20 Aug 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800391y (Source: Journal of Medicinal Chemistry)

 

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[genetics] abrogation of t cell quiescence characterizes patients at high ris...
by Proceedings of the National Academy of Sciences
19 Aug 2008 at 6:00am
Clinically isolated syndrome (CIS) refers to the earliest clinical manifestation of multiple sclerosis (MS). Currently there are no prognostic biological... (Source: Proceedings of the National Academy of Sciences)
The multidisciplinary team in multiple sclerosis: harnessing the array of dia...
by Medscape FamilyMedicine Headlines
18 Aug 2008 at 6:00pm
Review the latest advances in multiple sclerosis diagnosis and treatment. (Source: Medscape FamilyMedicine Headlines)

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